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Article

Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.

Antimicrobial agents and chemotherapy - 1 Aug 2000

Korsinczky M, Chen N, Kotecka B, Saul A, Rieckmann K, Cheng Q

Abstract excerpt

Atovaquone is the major active component of the new antimalarial drug Malarone. Considerable evidence suggests that malaria parasites become resistant to atovaquone quickly if atovaquone is used as a sole agent. The mechanism by which the parasite develops resistance to atovaquone is not yet fully understood. Atovaquone has been shown to inhibit the cytochrome bc(1) (CYT bc(1)) complex of the electron transport...

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Identifiers

PMID: 10898682
DOI: 10.1128/AAC.44.8.2100-2108.2000
PMCID: PMC90020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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