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Article

Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone.

Molecular and biochemical parasitology - 30 Nov 1999

Syafruddin D, Siregar J E, Marzuki S

Abstract excerpt

The molecular lesions which underlie the resistance of the malaria parasites to atovaquone, a coenzyme Q analogue, were investigated. Resistant clones of Plasmodium berghei ANKA strain were isolated following prolonged propagation in mice in the presence of increasing doses of the drug, and their...

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Identifiers

PMID: 10593174
DOI: 10.1016/s0166-6851(99)00148-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10593174-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone.PMID 10593174Read ↗

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Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.Semantic proximity Read ↗

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene.Semantic proximity Read ↗

Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?Semantic proximity Read ↗

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein ExpressionSemantic proximity Read ↗

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Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum.Semantic proximity Read ↗

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