Article
Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle.
The Journal of infectious diseases - 5 Jan 2022
Chiu Joy E, Renard Isaline, George Santosh, Pal Anasuya C, Alday P Holland, Narasimhan Sukanya, Riscoe Michael K, Doggett J Stone, Ben Mamoun Choukri
Abstract excerpt
Human babesiosis is an emerging tick-borne malaria-like illness caused by Babesia parasites following their development in erythrocytes. Here, we show that a mutation in the Babesia microti mitochondrial cytochrome b (Cytb) that confers resistance to the antibabesial drug ELQ-502 decreases parasite fitness in the arthropod vector. Interestingly, whereas the mutant allele does not affect B. microti fitness during...
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