Article
Frequencies of the -330 (T --> G) IL-2 and -590 (T --> C) IL-4 gene polymorphisms in a population from south-eastern Brazil.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Aug 2002
Scarel-Caminaga R M, Trevilatto P C, Souza A P, Brito R B, Line S R P
Abstract excerpt
Polymorphisms in the promoter regions of cytokine genes may affect their transcription. A T/G substitution at position -330 of the interleukin-2 (IL-2) gene and a T/C substitution at position -590 of the interleukin-4 (IL-4) gene have been described previously. The -590 (T --> C) IL-4 gene polymorphism was associated with asthma and atopy in US and Japanese populations. Population genetics is a useful tool for...
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