Article
Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.
PLoS genetics - 1 Mar 2014
Georgi Benjamin, Craig David, Kember Rachel L, Liu Wencheng, Lindquist Ingrid, Nasser Sara, Brown Christopher, Egeland Janice A, Paul Steven M, Bućan Maja
Abstract excerpt
Bipolar disorder is a common, heritable mental illness characterized by recurrent episodes of mania and depression. Despite considerable effort to elucidate the genetic underpinnings of bipolar disorder, causative genetic risk factors remain elusive. We conducted a comprehensive genomic analysis of bipolar disorder in a large Old Order Amish pedigree. Microsatellite genotypes and high-density SNP-array genotypes...
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