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Article

CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.

Journal of leukocyte biology - 1 Apr 2005

Bergholdt Regine, Taxvig Camilla, Eising Stefanie, Nerup Jørn, Pociot Flemming

Abstract excerpt

Type 1 diabetes (T1D) is a multifactorial disease with genetic and environmental components involved. Recent studies of an animal model of T1D, the Komeda diabetes-prone rat, have demonstrated that the Casitas-B-lineage lymphoma b (cblb) gene is a major susceptibility gene in the development of diabetes and other autoimmune features of this rat. As a result of the inhibitory role of Cbl-b in T cell costimulation,...

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Share to Antigens, Differentiation
Share to CTLA-4 Antigen
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fc Fragments

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Share to Proto-Oncogene Proteins c-cbl

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Source

Identifiers

PMID: 15629882
DOI: 10.1189/jlb.0904524

Genes

CBLB
CTLA4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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