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Article

Identification and functional analysis of CBLB mutations in type 1 diabetes.

Biochemical and biophysical research communications - 28 Mar 2008

Yokoi Norihide, Fujiwara Yuuka, Wang He-Yao, Kitao Mai, Hayashi Chihiro, Someya Tomohiro, Kanamori Masao, Oiso Yutaka, Tajima Naoko, Yamada Yuichiro, Seino Yutaka, Ikegami Hiroshi, Seino Susumu

Abstract excerpt

Casitas B-lineage lymphoma b (Cblb) is a negative regulator of T-cell activation and dysfunction of Cblb in rats and mice results in autoimmunity. In particular, a nonsense mutation in Cblb has been identified in a rat model of autoimmune type 1 diabetes. To clarify the possible involvement of CB...

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Source

Identifiers

PMID: 18201552
DOI: 10.1016/j.bbrc.2008.01.032

Genes

CBLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18201552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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