Article
Characterization of LDL particle size among carriers of a defective or a null mutation in the lipoprotein lipase gene: the Québec LIPD Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2002
Ruel Isabelle L, Gaudet Daniel, Perron Patrice, Bergeron Jean, Julien Pierre, Lamarche Benoît
Abstract excerpt
OBJECTIVE: The objective of the present study was to compare the impact of the null P207L and defective D9N mutations in the LPL gene on LDL particle size among heterozygous carriers. METHODS AND RESULTS: LDL particle size was measured on whole plasma by 2% to 16% non-denaturing polyacrylamide gradient gel electrophoresis in a cohort of 206 heterozygous carriers of either the P207L or the D9N mutation. The P207L...
Topics
- Cohort Studies
- Diabetes Mellitus, Type 2
- Electrophoresis, Polyacrylamide Gel
- Female
- Genetic Carrier Screening
- Genetic Testing
- Humans
- Lipid Metabolism, Inborn Errors
- Lipoprotein Lipase
- Lipoproteins, LDL
- Male
- Middle Aged
- Molecular Weight