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Estimation of single nucleotide polymorphism allele frequency in DNA pools by using Pyrosequencing.

Human genetics - 1 May 2002

Gruber Jonathan D, Colligan Peter B, Wolford Johanna K

Abstract excerpt

Positional cloning of genes underlying complex diseases, such as type 2 diabetes mellitus (T2DM), typically follows a two-tiered process in which a chromosomal region is first identified by genome-wide linkage scanning, followed by association analyses using densely spaced single nucleotide polymorphic markers to identify the causal variant(s). The success of genome-wide single nucleotide polymorphism (SNP)...

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PMID: 12073008
DOI: 10.1007/s00439-002-0722-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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