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Article

Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function.

Journal of neuroscience research - 1 May 2002

Teter B, Xu P-T, Gilbert J R, Roses A D, Galasko D, Cole G M

Abstract excerpt

The apolipoprotein E (apoE) epsilon 4 allele (apoE4) is a major risk factor for neurodegenerative conditions, including Alzheimer's disease (AD). A role for apoE in regeneration of synaptic circuitry after neural injury has been shown in several in vitro studies in which apoE3 supports neuronal sprouting better than apoE4. We evaluated sprouting in an in vitro mouse organotypic hippocampal slice culture system...

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Source

Identifiers

PMID: 12111863
DOI: 10.1002/jnr.10221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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