Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

12 Jul 2013

Abstract excerpt

BACKGROUND: The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurogenesis and neuroplasticity mechanisms
Share to Olfactory and Sensory Function Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23845000
DOI: 10.1186/1423-0127-20-49

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culturePMID 23845000Read ↗

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease RiskSemantic proximity Read ↗

Estrogen Facilitates Neurite Extension via Apolipoprotein E in Cultured Adult Mouse Cortical NeuronsSemantic proximity Read ↗

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease RiskSemantic proximity Read ↗

ApoE isoform-specific regulation of regeneration in the peripheral nervous systemSemantic proximity Read ↗

Human Apolipoprotein E Isoform‐Specific Differences in Neuronal Sprouting in Organotypic Hippocampal CultureSemantic proximity Read ↗

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Semantic proximity Read ↗

Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function.Semantic proximity Read ↗

ApoE isoform-dependent changes in hippocampal synaptic functionSemantic proximity Read ↗

In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.Semantic proximity Read ↗

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?Semantic proximity Read ↗

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.Semantic proximity Read ↗

The effects of the apoE4 genotype on the developing mouse retina.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.