Article
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Molecular and cellular biology - 1 May 2008
Bayascas Jose R, Wullschleger Stephan, Sakamoto Kei, García-Martínez Juan M, Clacher Carol, Komander David, van Aalten Daan M F, Boini Krishna M, Lang Florian, Lipina Christopher, Logie Lisa, Sutherland Calum, Chudek John A, van Diepen Janna A, Voshol Peter J, Lucocq John M, Alessi Dario R
Abstract excerpt
PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists. PDK1 interacts with phosphoinositides through a pleckstrin homology (PH) domain. To study the role of this interaction, we generated knock-in mice expressing a mutant of PDK1...
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