Article
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Oncogene - 14 Aug 2003
Martín Javier, Hunt Sarah L, Dubus Pierre, Sotillo Rocío, Néhmé-Pélluard Fanny, Magnuson Mark A, Parlow Albert F, Malumbres Marcos, Ortega Sagrario, Barbacid Mariano
Abstract excerpt
Lack of Cdk4 expression in mice leads to insulin-deficient diabetes and female infertility owing to a reduced number of pancreatic beta cells and prolactin-producing pituitary lactotrophs, respectively. Cdk4 null mice display also reduced body and organ size. Here, we show that Cdk4 is essential for the postnatal proliferation of pancreatic beta cells but not for embryonic neogenesis from ductal epithelial cells....
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