Article
Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: the core protein-encoding region.
Acta medica Okayama - 1 Jun 2002
Alam Shahjalal S, Nakamura Takashi, Naganuma Atsushi, Nozaki Akito, Nouso Kazuhiro, Shimomura Hiroyuki, Kato Nobuyuki
Abstract excerpt
We have shown that highly proofreading DNA polymerase is required for the polymerase chain reaction in the genetic analysis of hepatitis C virus (HCV). To clarify the status of HCV quasispecies in hepatic tissue using proofreading DNA polymerase, we performed a genetic analysis of the HCV core protein-encoding region in cancerous and noncancerous lesions derived from 4 patients with hepatocellular carcinoma. In...
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