Article
Comparative sequence analysis of the core- and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue.
Journal of medical virology - 1 Feb 2001
Rüster B, Zeuzem S, Krump-Konvalinkova V, Berg T, Jonas S, Severin K, Roth W K
Abstract excerpt
The sequence variability within the core- and non-structural 5 (NS5)-region of the hepatitis C virus (HCV) was investigated in tumor and non-tumor tissue of 8 patients with HCV-associated hepatocellular carcinoma (HCC). Analyses of multiple clones containing polymerase chain reaction-amplified HCV sequences revealed a significantly higher variability within the core-region of tumor tissue isolates than of...
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