Article
Distinct hepatitis C virus core and F protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection.
Hepatology (Baltimore, Md.) - 1 Dec 2007
Sobesky Rodolphe, Feray Cyrille, Rimlinger François, Derian Nicolas, Dos Santos Alexandre, Roque-Afonso Anne-Marie, Samuel Didier, Bréchot Christian, Thiers Valérie
Abstract excerpt
UNLABELLED: Hepatitis C virus (HCV) genetic variability may be involved in liver carcinogenesis. We investigated HCV core and corresponding putative F protein genetic variability in hepatocellular carcinoma (HCC) and cirrhotic nodules. Hepatocyte clusters from 7 patients with HCC and HCV1b-related cirrhosis were isolated via microdissection of HCC tissues and 2 nontumoral cirrhotic nodules. The HCV core...
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