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Article

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 1995

Diebold R J, Eis M J, Yin M, Ormsby I, Boivin G P, Darrow B J, Saffitz J E, Doetschman T

Abstract excerpt

Transforming growth factor beta 1 (TGF beta 1)-null mice die fro complications due to an early-onset multifocal inflammatory disorder. We show here that cardiac cells are hyperproliferative and that intercellular adhesion molecule 1 (ICAM-1) is elevated. To determine which phenotypes are primarily caused by a deficiency in TGF beta 1 from those that are secondary to inflammation, we applied immunosuppressive...

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Identifiers

PMID: 8618872
DOI: 10.1073/pnas.92.26.12215
PMCID: PMC40327

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Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.PMID 8618872Read ↗

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