Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

doi:10.1073/pnas.92.26.12215

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Article

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 1995

Diebold R J, Eis M J, Yin M, Ormsby I, Boivin G P, Darrow B J, Saffitz J E, Doetschman T

Abstract excerpt

Transforming growth factor beta 1 (TGF beta 1)-null mice die fro complications due to an early-onset multifocal inflammatory disorder. We show here that cardiac cells are hyperproliferative and that intercellular adhesion molecule 1 (ICAM-1) is elevated. To determine which phenotypes are primaril...

Topics

Animals
Animals, Newborn
Antibodies
Base Sequence
CD11 Antigens
DNA Primers
Genotype
Heterozygote
Homozygote
Immunotherapy
Inflammation
Leukocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Lymphocytes

Mice

Mice, SCID

Molecular Sequence Data

Myocardium

Source

Open in PubMed Open full text

Identifiers

PMID: 8618872
DOI: 10.1073/pnas.92.26.12215
PMCID: PMC40327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8618872-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.PMID 8618872Read ↗

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