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Article

Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.

Journal of virology - 1 May 2007

Priceputu Elena, Hanna Zaher, Hu Chunyan, Simard Marie-Chantal, Vincent Patrick, Wildum Steffen, Schindler Michael, Kirchhoff Frank, Jolicoeur Paul

Abstract excerpt

We previously reported that the human immunodeficiency virus type 1 NL4-3 Nef is necessary and sufficient to induce a severe AIDS-like disease in transgenic (Tg) mice when the protein is expressed under the regulatory sequences of the human CD4 gene. We have now assayed additional Nef alleles (SF2, JR-CSF, YU10x, and NL4-3 [T71R] Nef alleles), including some from long-term nonprogressors (AD-93, 032an, and 039nm...

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Topics

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Share to CD4 Antigens
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Gene Products, nef

Share to Immunologic Memory

Share to Immunoprecipitation

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Regulatory Elements, Transcriptional

Source

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Identifiers

PMID: 17314161
DOI: 10.1128/JVI.02691-06
PMCID: PMC1900134

Genes

PAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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