Article
Role of cardiac myocyte tissue factor in heart hemostasis.
Journal of thrombosis and haemostasis : JTH - 1 Aug 2007
Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley R E, Marynen P, Mackman N
Abstract excerpt
BACKGROUND: The tissue-specific pattern of tissue factor (TF) expression suggests that it plays a major role in the hemostatic protection of specific organs, such as the heart and lung. In support of this notion, we found that mice expressing very low levels of TF exhibit hemostatic defects in the heart and lung. Hemosiderosis and fibrosis are observed in the hearts of all low TF mice as early as 3 months of age....
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