Article
Association of a missense mutation of the laminin alpha2 gene with tuberculoid type of leprosy in Indonesian patients.
Tropical medicine & international health : TM & IH - 1 Jul 2002
Wibawa Tri, Soebono Hardyanto, Matsuo Masafumi
Abstract excerpt
Leprosy, an infection caused by Mycobacterium leprae, has a specific tropism for the myelinating Schwann cells of peripheral nerves. Recently, the G domain of laminin alpha2 has been shown to be a mediator for M. leprae to bind to alpha-dystroglycan in Schwann cells. In order to analyse the association of leprosy with the mediator, three genetic polymorphisms encoding the G domain of the laminin alpha2 chain were...
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