Article
Bacterial and host-derived cationic proteins bind alpha2-laminins and enhance Mycobacterium leprae attachment to human Schwann cells.
Microbes and infection - 1 Oct 2000
de Melo Marques M A, Mahapatra S, Nandan D, Dick T, Sarno E N, Brennan P J, Vidal Pessolani M C
Abstract excerpt
It has recently been demonstrated that laminin alpha2 chains present on the surface of Schwann cells are involved in the process of attachment of Mycobacterium leprae to these cells. In this study, a protein in the M. leprae cell wall that was found to be capable of binding alpha2-containing laminins (merosin) was isolated and characterized. The M. leprae laminin-binding protein was identified as a 21-kDa...
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