Article
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.
FEMS immunology and medical microbiology - 1 Jul 2001
Kang T J, Chae G T
Abstract excerpt
Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections and the mutations in the TLR2 have been shown to confer the susceptibility to severe infection with mycobacteria. To define this, we screened the intracellular domain of TLR2 in 131 subjects. Groups of 45 lepromatous and 41 tuberculoid leprosy (TT) patients and 45 controls were investigated. Ten subjects among the...
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