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Article

The role of ERBB2 gene polymorphisms in leprosy susceptibility.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases - 1 Jan 2000

Rêgo Jamile Leão, Oliveira Joyce Moura, Santana Nadja de Lima, Machado Paulo Roberto Lima, Castellucci Léa Cristina

Abstract excerpt

Mycobacterium leprae infects skin and peripheral nerves causing deformities and disability. The M. leprae bacterium binds to ErbB2 on the Schwann cell surface causing demyelination and favoring spread of the bacilli and causing nerve injury. Polymorphisms at the ERBB2 gene were previously investigated as genetic risk factors for leprosy in two Brazilian populations but with inconsistent results. Herein we extend...

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Source

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Identifiers

PMID: 25636184
DOI: 10.1016/j.bjid.2014.12.008
PMCID: PMC9425388

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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