Article
The genotype of mice influences the autoimmune response to spliceosome proteins induced by cytomegalovirus gB immunization.
Clinical and experimental immunology - 1 Jul 2002
Lipes J, Skamene E, Newkirk M M
Abstract excerpt
In previous studies we have established a link between cytomegalovirus (CMV) infection and an autoimmune response to the U1-70 k protein of the spliceosome in man. This autoimmune response, generally referred to as the anti-RNP (ribonucleoprotein) antibodies, is observed in about 30% of patients with systemic lupus erythematosus (SLE). We have also found that the CMV glycoprotein B (CMV gB) when expressed in a...
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