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Article

The K/BxN mouse model of inflammatory arthritis: theory and practice.

Methods in molecular medicine - 1 Jan 2007

Monach Paul, Hattori Kimie, Huang Haochu, Hyatt Elzbieta, Morse Jody, Nguyen Linh, Ortiz-Lopez Adriana, Wu Hsin-Jung, Mathis Diane, Benoist Christophe

Abstract excerpt

Mice expressing the KRN T cell receptor transgene and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, and serum from these mice causes similar arthritis in a wide range of mouse strains, owing to pathogenic autoantibodies to glucose-6-phosphate isomerase (GPI). This model has been useful for the investigation of the development of autoimmunity (K/BxN transgenic mice) and...

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Identifiers

PMID: 17983155
DOI: 10.1007/978-1-59745-402-5_20

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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