Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arthritogenic Monoclonal Antibodies from K/BxN Mice

15 Apr 2002

Abstract excerpt

Arthritis in the K/BxN mouse model is provoked by pathogenic antibodies (Abs) directed against a ubiquitously expressed protein, glucose-6-phosphate isomerase (GPI). To begin dissecting the repertoire of arthritogenic immunoglobulins (Igs) in the K/BxN model, and to provide a basis for comparison with RA patients we have generated anti-GPI monoclonal Abs (mAbs) from spontaneously activated B cells in the lymphoid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11956298
DOI: 10.1084/jem.20011941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arthritogenic Monoclonal Antibodies from K/BxN MicePMID 11956298Read ↗

The K/BxN mouse model of inflammatory arthritis: theory and practice.Semantic proximity Read ↗

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.Semantic proximity Read ↗

Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.Semantic proximity Read ↗

Recombinant Human IgG1-Hexamer Reduces Pathogenic Autoantibodies in the K/BxN Mouse Model of Arthritis Independent of FcRnSemantic proximity Read ↗

Deletion of the antiphospholipid syndrome autoantigen β2 -glycoprotein I potentiates the lupus autoimmune phenotype in a Toll-like receptor 7-mediated murine model.Semantic proximity Read ↗

Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35).Semantic proximity Read ↗

Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production.Semantic proximity Read ↗

Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisSemantic proximity Read ↗

Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice.Semantic proximity Read ↗

Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.Semantic proximity Read ↗

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory ArthritisSemantic proximity Read ↗

A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.