Article
Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2001
Haywood M E, Vyse T J, McDermott A, Thompson E M, Ida A, Walport M J, Izui S, Morley B J
Abstract excerpt
Retroviral envelope glycoprotein gp70 is present in the sera of immunologically normal and autoimmune-prone strains of mice. However, only lupus-prone mice spontaneously develop gp70-anti-gp70 immune complexes (gp70IC), and these have been implicated in the development of nephritis. We investigated the genetic factors that affect the production of both free serum gp70 and gp70IC in the lupus-prone BXSB mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.