Article
Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2001
Haywood M E, Vyse T J, McDermott A, Thompson E M, Ida A, Walport M J, Izui S, Morley B J
Abstract excerpt
Retroviral envelope glycoprotein gp70 is present in the sera of immunologically normal and autoimmune-prone strains of mice. However, only lupus-prone mice spontaneously develop gp70-anti-gp70 immune complexes (gp70IC), and these have been implicated in the development of nephritis. We investigat...
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