Article
Linkage analysis in families with recurrent neuroblastoma.
Annals of the New York Academy of Sciences - 1 Jun 2002
Perri Patrizia, Longo Luca, McConville Carmel, Cusano Roberto, Rees Sally A, Seri Marco, Conte Massimo, Romeo Giovanni, Devoto Marcella, Tonini Gian Paolo
Abstract excerpt
Neuroblastoma is a neural crest-derived tumor of childhood with a serious prognosis; only 20% of patients with stage 4 disease survive 5 years from diagnosis. Mechanisms involved in neuroblastoma development are unclear, but the engagement of many neuroblastoma-related gene(s) is suggested by specific chromosomal alterations. Most prominent among these is the amplification of the MYCN oncogene and the deletion of...
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