Article
Familial predisposition to neuroblastoma does not map to chromosome band 1p36.
Cancer research - 1 Aug 1996
Maris J M, Kyemba S M, Rebbeck T R, White P S, Sulman E P, Jensen S J, Allen C, Biegel J A, Yanofsky R A, Feldman G L, Brodeur G M
Abstract excerpt
Familial predisposition to neuroblastoma, a common embryonal cancer of childhood, segregates as an autosomal dominant trait with high penetrance. It is therefore likely that neuroblastoma susceptibility is due to germ line mutations in a tumor suppressor gene. Cytogenetic, functional, and molecular studies have implicated chromosome band 1p36 as the most likely region to contain a suppressor gene involved in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.