Article
Exclusion of candidate genes and chromosomal regions in familial neuroblastoma.
International journal of molecular medicine - 1 Jan 2001
Tonini G P, McConville C, Cusano R, Rees S A, Dagnino M, Longo L, De Bernardi B, Conte M, Garaventa A, Romeo G, Devoto M, Seri M
Abstract excerpt
Two families with recurrence of neuroblastoma one Italian and one British with three and two affected children respectively were genotyped using polymorphic markers on chromosome 1 spanning the p32-p36 region frequently deleted in neuroblastoma tumor cells. Linkage to this region was excluded by haplotype inspection and negative lod scores. Furthermore, the exclusion of genes involved in neurocristopathies...
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