Familial neuroblastoma: a complex heritable disease.

doi:10.1016/s0304-3835(03)00080-6

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Article

Familial neuroblastoma: a complex heritable disease.

Cancer letters - 18 Jul 2003

Tonini Gian Paolo, Longo Luca, Coco Simona, Perri Patrizia

Abstract excerpt

Genomic surveys carried out over the years have revealed a great heterogeneity in the pattern of genetic aberrations occurring in neuroblastoma (NB) cells. Studies on familial NB could lead to the discovery of susceptibility genes and their contribution to the development of the disease. The two-hit hypothesis is considered the most consistent model of inherited predisposition to NB, but an oligogenic inheritance...

Topics

Chromosomes, Human
Female
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Humans
Loss of Heterozygosity
Male
Nervous System Neoplasms
Neuroblastoma
Pedigree

Source

Open in PubMed

Identifiers

PMID: 12880958
DOI: 10.1016/s0304-3835(03)00080-6

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