Article
K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.
In vivo (Athens, Greece) - 1 Jan 2000
Margetis Nikolaos, Kouloukoussa Myrsini, Pavlou Kyriaki, Vrakas Spyridon, Mariolis-Sapsakos Theodoros
Abstract excerpt
K-ras oncogene is a key factor in colorectal cancer. Based on published and our data we propose that K-ras could be the oncogene responsible for the inactivation of the tumor-suppressor gene APC, currently considered as the initial step in colorectal tumorigenesis. K-ras fulfills the criteria of the oncogene-induced DNA damage model, as it can provoke well-established causes for inactivating tumor-suppressors,...
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