K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.

doi:10.21873/invivo.11091

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Article

K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.

In vivo (Athens, Greece) - 1 Jan 2000

Margetis Nikolaos, Kouloukoussa Myrsini, Pavlou Kyriaki, Vrakas Spyridon, Mariolis-Sapsakos Theodoros

Abstract excerpt

K-ras oncogene is a key factor in colorectal cancer. Based on published and our data we propose that K-ras could be the oncogene responsible for the inactivation of the tumor-suppressor gene APC, currently considered as the initial step in colorectal tumorigenesis. K-ras fulfills the criteria of...

Topics

Adenomatous Polyposis Coli Protein
Cell Transformation, Neoplastic
Colon
Colorectal Neoplasms
DNA Breaks, Double-Stranded
Humans
Mutation
Proto-Oncogene Proteins p21(ras)
Reactive Oxygen Species

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