Article
Pathogenesis of colorectal cancer.
The Surgical clinics of North America - 1 Oct 2002
Jass Jeremy R
Abstract excerpt
It is frequently stated that all but a few colorectal cancers arise in adenomatous polyps, in turn initiated by APC mutation. Moderation of this view is now required. The proportion of colorectal cancers that arises in a polypoid adenoma is likely to be around 70% [39,61]. The pre-eminence of the adenoma-carcinoma model has been influenced by two factors: (1) the need to avoid overtreatment of innocent lesions,...
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