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Article

Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock.

Cell - 17 May 2002

Nitabach Michael N, Blau Justin, Holmes Todd C

Abstract excerpt

Electrical silencing of Drosophila circadian pacemaker neurons through targeted expression of K+ channels causes severe deficits in free-running circadian locomotor rhythmicity in complete darkness. Pacemaker electrical silencing also stops the free-running oscillation of PERIOD (PER) and TIMELESS (TIM) proteins that constitutes the core of the cell-autonomous molecular clock. In contrast, electrical silencing...

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Source

Identifiers

PMID: 12086605
DOI: 10.1016/s0092-8674(02)00737-7

Genes

TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock.PMID 12086605Read ↗

Drosophila free-running rhythms require intercellular communication.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

Role of molecular oscillations in generating behavioral rhythms in Drosophila.Semantic proximity Read ↗

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Intercellular coupling confers robustness against mutations in the SCN circadian clock network.Semantic proximity Read ↗

The transcription factor Mef2 is required for normal circadian behavior in Drosophila.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

The Drosophila Receptor Protein Tyrosine Phosphatase LAR Is Required for Development of Circadian Pacemaker Neuron Processes That Support Rhythmic Activity in Constant Darkness But Not during Light/Dark Cycles.Semantic proximity Read ↗

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