Article
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
Cell - 17 May 2002
Taniguchi Toshiyasu, Garcia-Higuera Irene, Xu Bo, Andreassen Paul R, Gregory Richard C, Kim Seong-Tae, Lane William S, Kastan Michael B, D'Andrea Alan D
Abstract excerpt
Fanconi anemia (FA) and ataxia telangiectasia (AT) are clinically distinct autosomal recessive disorders characterized by spontaneous chromosome breakage and hematological cancers. FA cells are hypersensitive to mitomycin C (MMC), while AT cells are hypersensitive to ionizing radiation (IR). Here, we identify the Fanconi anemia protein, FANCD2, as a link between the FA and ATM damage response pathways. ATM...
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