Article
Increased expression of COX-2 in the development of human lung cancers.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer - 1 Jan 2002
Takahashi Takashi, Kozaki Ken-ichi, Yatabe Yasushi, Achiwa Hiroyuki, Hida Toyoaki
Abstract excerpt
It is well accepted that an increase in the expression of cyclooxygenase-2 (COX-2), a key inducible enzyme involved in the production of prostaglandins and other eicosanoids, may play a significant role in carcinogenesis in addition to its well-known role in inflammatory reactions. Whereas previous studies were largely confined to colorectal tumorigenesis, we have shown that a significantly increased expression...
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