Article
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
Oncotarget - 17 Nov 2015
Pan Yong, Jiang Yan, Tan Lin, Ravoori Murali K, Gagea Mihai, Kundra Vikas, Fischer Susan M, Yang Peiying
Abstract excerpt
The purpose of this study was to identify the role COX-2 plays in K-ras-induced lung carcinogenesis. We crossed COX-2-homozygous knockout mice with K-rasLA1 (G12D) expressing mice to obtain COX-2-deficient mice with K-ras expression (K-ras/COX-2(-/-) mice) and COX-2 wild type mice with K-ras expression (K-ras mice). At 3.5 months of age, the K-ras/COX-2(-/-) mice had significantly fewer lung adenocarcinomas and...
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