Article
Immunohistochemical expression of cyclooxygenase-2 in skin cancers.
Journal of cutaneous pathology - 1 Jul 2001
Kagoura M, Toyoda M, Matsui C, Morohashi M
Abstract excerpt
BACKGROUND: Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, catalyses the conversion of arachidonic acid to prostanoids. There are two different isoforms of COX, referred to as COX-1 and COX-2. Overexpression of COX-2 has been demonstrated in various neoplasms, such as experimentally promoted tumors, gastrointestinal cancers and breast tumors. METHODS: In this study, we used...
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