Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C.

Anatomical record (Hoboken, N.J. : 2007) - 1 Oct 2009

Liu Huidong, Yang Yanmei, Xiao Jianbing, Lv Yanhong, Liu Yan, Yang Huike, Zhao Linghui

Abstract excerpt

Most experimental work addressing cyclooxygenase-2 (COX-2) inhibitor has focused on suppressing hematogenic spread. Little is known about the mechanism by which this inhibitor can also block lymphatic metastasis. Here, the effects of COX-2 inhibitor on vascular endothelial growth factor-C (VEGF-C) expression, lymphangiogenesis and lymph node metastasis were investigated. Utilizing the highly metastatic human lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Cyclooxygenase 2 Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dinoprostone

Share to Lymphangiogenesis

Share to Lymphatic Metastasis

Share to Pyrazoles

Share to Vascular Endothelial Growth Factor C

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 19685508
DOI: 10.1002/ar.20940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C.PMID 19685508Read ↗

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis.Semantic proximity Read ↗

Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis.Semantic proximity Read ↗

Inhibition of miR-214 expression by small molecules alleviates head and neck cancer metastasis by targeting ALCAM/TFAP2 signalingSemantic proximity Read ↗

Increased expression of COX-2 in the development of human lung cancers.Semantic proximity Read ↗

RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways.Semantic proximity Read ↗

Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model.Semantic proximity Read ↗

Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells.Semantic proximity Read ↗

Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity.Semantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma.Semantic proximity Read ↗

ERK5 mediates pro-tumorigenic phenotype in non-small lung cancer cells induced by PGE2.Semantic proximity Read ↗

Immunohistochemical expression of cyclooxygenase-2 in skin cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.