Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C.

doi:10.1002/ar.20940

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Article

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C.

Anatomical record (Hoboken, N.J. : 2007) - 1 Oct 2009

Liu Huidong, Yang Yanmei, Xiao Jianbing, Lv Yanhong, Liu Yan, Yang Huike, Zhao Linghui

Abstract excerpt

Most experimental work addressing cyclooxygenase-2 (COX-2) inhibitor has focused on suppressing hematogenic spread. Little is known about the mechanism by which this inhibitor can also block lymphatic metastasis. Here, the effects of COX-2 inhibitor on vascular endothelial growth factor-C (VEGF-C) expression, lymphangiogenesis and lymph node metastasis were investigated. Utilizing the highly metastatic human lung...

Topics

Adenocarcinoma
Animals
Celecoxib
Cell Line, Tumor
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Dinoprostone
Humans
Lung Neoplasms
Lymphangiogenesis
Lymphatic Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Phenotype

Source

Open in PubMed

Identifiers

PMID: 19685508
DOI: 10.1002/ar.20940

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Pyrazoles

Sulfonamides

Vascular Endothelial Growth Factor C