Article
[Effects of TIMP-2 gene transfection on biological behaviors of a metastatic human lung carcinoma cell line].
Zhonghua yi xue za zhi - 1 Sept 1997
Li H, Fang W, Shi Z
Abstract excerpt
OBJECTIVES: To explore the suppressive effects of tissue inhibitor of metalloproteinase 2 (TIMP-2) on malignant phenotype of human carcinoma cells and to evaluate its potential application in cancer gene therapy. METHODS: A man malian expression vector containing TIMP-2 cDNA was constructed and transfected into a metastatic human lung carcinoma cell line PG. In vitro and in vivo tests such as Northern blotting,...
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