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Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients.

Atherosclerosis - 1 Oct 2010

Katakami Naoto, Kaneto Hideaki, Matsuoka Taka-aki, Takahara Mitsuyoshi, Imamura Kenichi, Ishibashi Fukashi, Kanda Tsutomu, Kawai Koichi, Osonoi Takeshi, Kashiwagi Atsunori, Kawamori Ryuzo, Matsuhisa Munehide, Shimomura Iichiro, Yamasaki Yoshimitsu

Abstract excerpt

OBJECTIVE: It is believed that oxidative stress, which is provoked in patients with diabetes, plays critical roles in the pathogenesis of myocardial infarction (MI). We simultaneously determined 5 relatively common genetic variants related to oxidative stress and evaluated the combined effect on MI. METHODS: We enrolled 3819 Japanese type 2 diabetic subjects (males 60.8%, 60.6±10.0 years old) and determined their...

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Source

Identifiers

PMID: 20598694
DOI: 10.1016/j.atherosclerosis.2010.06.010

Genes

CYBA
GCLM
MPO
NOS3
SOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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