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Article

Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function.

Circulation - 23 Sept 2003

Nakamura Shin-ichi, Sugiyama Seigo, Fujioka Daisuke, Kawabata Ken-ichi, Ogawa Hisao, Kugiyama Kiyotaka

Abstract excerpt

BACKGROUND: The minor -588T allele of polymorphism -588C/T of a modifier subunit gene in glutamate-cysteine ligase (GCLM), a rate-limiting enzyme for glutathione (GSH) synthesis, was associated with lower plasma GSH levels and was a risk factor for myocardial infarction. METHODS AND RESULTS: We e...

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Source

Identifiers

PMID: 12975258
DOI: 10.1161/01.CIR.0000091255.63645.98

Genes

GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12975258-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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