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Article

IS6110 in oriC affects the morphology and growth of Mycobacterium tuberculosis and attenuates virulence in mice.

Tuberculosis (Edinburgh, Scotland) - 1 Nov 2008

Casart Yveth, Turcios Lilia, Florez Ingrid, Jaspe Rossana, Guerrero Elba, de Waard Jacobus, Aguilar Diana, Hérnandez-Pando Rogelio, Salazar Leiria

Abstract excerpt

The IS6110 element is widely used in studies of molecular epidemiology of tuberculosis and it is considered the gold standard for genotyping Mycobacterium tuberculosis strains. Because of its high frequency of transposition, IS6110 is probably a major contributor to the evolution of M. tuberculosis. Nevertheless, very few studies of the effect of IS6110 insertions on the virulence of M. tuberculosis have been...

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PMID: 18534910
DOI: 10.1016/j.tube.2008.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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