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Nhlh2

22 Sept 2008

Abstract excerpt

In Brief In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise. Evidence from mice and humans indicates that nescient helix-loop-helix 2 (Nhlh2)...

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PMID: 18815487
DOI: 10.1097/jes.0b013e31818782dd

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