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Article

Functional analysis of -351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-kappaB.

Genes and immunity - 1 Jun 2009

Early S B, Huyett P, Brown-Steinke K, Borish L, Steinke J W

Abstract excerpt

Genetic studies have shown linkages for asthma to the chromosomal region 5q31-q33 in humans that includes the IL-9 gene. An A-to-G base substitution has been identified at bp -351 in the IL-9 promoter. The role of this polymorphism in IL-9 promoter function was assessed utilizing CD4+ T cells purified from individuals with one or two of the G alleles in comparison to those homozygous for the wild-type A. The...

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Identifiers

PMID: 19387455
DOI: 10.1038/gene.2009.28
PMCID: PMC2702712

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Source receipt: pubmed, retrieved 7 Sept 2026.

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