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Article

Functional genetic variants of the IFN-λ3 (IL28B) gene and transcription factor interactions on its promoter.

Cytokine - 1 Jun 2021

Roy Subhajit, Guha Roy Debarati, Bhushan Anand, Bharatiya Seema, Chinnaswamy Sreedhar

Abstract excerpt

Interferon lambda 3 (IFN-λ3 or IFNL3, formerly IL28B), a type III interferon, modulates immune responses during infection/inflammation. Several human studies have reported an association of single nucleotide polymorphisms (SNP) in the IFNL3 locus with expression level of IFNL3. Previous genetic studies, in the context of hepatitis C virus infections, had predicted three regulatory SNPs: rs4803219, rs28416813 and...

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Identifiers

PMID: 33725487
DOI: 10.1016/j.cyto.2021.155491
PMCID: PMC7611124

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