Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I.

Immunogenetics - 1 Jan 2003

Jüliger Simone, Bongartz Martina, Luty Adrian J F, Kremsner Peter G, Kun Jürgen F J

Abstract excerpt

We analyzed a single nucleotide polymorphism (SNP) at position -56 (T-->C) in the promoter region of the gene encoding the human interferon-gamma receptor ligand-binding chain I (IFN-gammaR1). The mutation was present at similar frequencies in Gabonese children with either mild or severe malaria. Functional investigations of the promoter in a transfected human B-cell line showed lower levels of luciferase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon gamma Receptor

Share to Promoter Regions, Genetic

Share to Receptors, Interferon

Share to Transcription Factors

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12557053
DOI: 10.1007/s00251-002-0516-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I.PMID 12557053Read ↗

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Semantic proximity Read ↗

Interferon-gamma receptor 1 promoter polymorphisms: population distribution and functional implications.Semantic proximity Read ↗

A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.Semantic proximity Read ↗

A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection.Semantic proximity Read ↗

Interferon-gamma receptor-1 gene promoter polymorphisms and susceptibility to leprosy in children of a single family.Semantic proximity Read ↗

Promoter and intron-1 region polymorphisms in the IFNG gene in patients with hepatitis E.Semantic proximity Read ↗

Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection.Semantic proximity Read ↗

Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis.Semantic proximity Read ↗

A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B.Semantic proximity Read ↗

In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.Semantic proximity Read ↗

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Semantic proximity Read ↗

Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.