Article
Association of the -183 polymorphism in the IFN-gamma gene promoter with hepatitis B virus infection in the Chinese population.
Journal of clinical laboratory analysis - 1 Jan 2005
Qi Suxia, Cao Bangwei, Jiang Mingwei, Xu Changqing, Dai Yue, Li Kun, Wang Kun, Ke Yang, Ning Tao
Abstract excerpt
Interferon-gamma (IFN-gamma) is a pleiotropic cytokine that plays an important role in regulating cellular immune responses. Regulation of IFN-gamma expression is considered to be strictly controlled at the transcriptional level. Two single-nucleotide polymorphisms (SNPs) within the human IFN-gamma promoter (at positions -183 and -155) are considered to influence the promoter activity by altering the acting...
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