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Article

Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase.

Protein science : a publication of the Protein Society - 1 Jul 2002

Schneider Benoit, Norda Ameli, Karlsson Anna, Veron Michel, Deville-Bonne Dominique

Abstract excerpt

Nucleoside diphosphate (NDP) kinase is transiently phosphorylated on a histidine of the active site during the catalytic cycle. In the presence of a nucleotide acceptor, the phosphohistidine bond is unstable and the phosphate is transferred to the acceptor in less than 1 msec. We describe the synthesis of an analog of the phosphoenzyme intermediate with an inactive mutant of NDP kinase in which the catalytic...

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Identifiers

PMID: 12070317
DOI: 10.1110/ps.0204702
PMCID: PMC2373669

Genes

NDP
DTNB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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