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Article

Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.

Development (Cambridge, England) - 1 Jul 2002

McFadden David G, McAnally John, Richardson James A, Charité Jeroen, Olson Eric N

Abstract excerpt

Basic helix-loop-helix (bHLH) transcription factors control developmental decisions in a wide range of embryonic cell types. The HLH motif mediates homo- and heterodimerization, which juxtaposes the basic regions within the dimeric complex to form a bipartite DNA binding domain that recognizes a DNA consensus sequence known as an E-box. eHAND and dHAND (also known as HAND1 and HAND2) are closely related bHLH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12070084
DOI: 10.1242/dev.129.13.3077

Genes

HAND1
HAND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.PMID 12070084Read ↗

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Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Semantic proximity Read ↗

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.Semantic proximity Read ↗

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